N,N-Dimethylformamide (DMF) is widely used as a solvent for pharmaceuticals.N,N-Dimethylformamide is a bipolar pro-primary solvent whose physicochemical properties make it suitable for use as a solvent in capillary electrophoresis (CE).

N,N-Dimethylformamide (DMF) is a clear liquid that is widely used in industry as a solvent, additive or intermediate due to its wide miscibility with water and most common organic solvents. Dimethylformamide solutions are used in the processing of polymer fibers, films and surface coatings; to facilitate the spinning of acrylic fibers; in the production of wire enamels; and as a crystallization medium in the pharmaceutical industry.

DMF is also used in formylation reactions with alkyl lithium or Grignard reagents.DMF is also used as a reagent in the synthesis of bouvialdehyde and in the Vilsmeier-Haack reaction. It is also a catalyst for the synthesis of acyl chlorides. It is used to separate and refine crude oil from olefinic gases.DMF, together with methylene chloride, is used as a remover for varnishes or paints. It is also used in the manufacture of adhesives, fibers and films.

Basic information

Dimethylformamide(DMF) applications

Application 1:Used as analytical reagent and solvent for vinyl resin and acetylene.

Application 2:It is an excellent organic solvent, used as a solvent for polyurethane, polyacrylonitrile, and polyvinyl chloride, and also used as an extractant, a raw material for medicine and pesticide insecticide.

Application 3:Dimethylformamide is not only a chemical raw material with a wide range of uses, but also an excellent solvent with a wide range of uses.

It can be used for wet spinning of synthetic fibers such as polyacrylonitrile fibers, and the synthesis of polyurethane; it is used for plastic film making; it can also be used as a paint remover for removing paint; it can also dissolve some low-solubility pigments, so that the pigments have dyes specialty.

Dimethylformamide can be used for aromatic extraction and separation and recovery of butadiene from C4 fractions and isoprene from C5 fractions, and can also be used as an effective reagent for the separation of non-hydrocarbon components from paraffin . It has good selectivity for the solubility of isophthalic acid and terephthalic acid: isophthalic acid is more soluble in dimethylformamide than terephthalic acid, solvent extraction in dimethylformamide or Partially crystallized, the two can be separated.

In the petrochemical industry, dimethylformamide can be used as a gas absorbent to separate and refine gases. In organic reactions, dimethylformamide is not only widely used as a solvent for the reaction, but also an important intermediate in organic synthesis.

In the pesticide industry, it can be used to produce ciprofloxacin; in the pharmaceutical industry, it can be used to synthesize sulfadiazine, doxycycline, cortisone, vitamin B6, iodine, quercetin, pyrantel, N-formylsarcomin, antitumor Amino acid, methoxyfen mustard, Bian nitrogen mustard, cyclohexyl nitrosourea, furofluorouracil, hemostatic acid, bepartame, megestrol, bilevita, chlorpheniramine, etc. DMF has a catalytic effect in the reactions of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, so that the reaction temperature is lowered and the product purity is improved.

Application 4:Reagent for non-aqueous titration, solvent for vinyl resin and acetylene, organic synthesis, photometric determination, gas chromatography stationary solution (maximum temperature 50℃, solvent is methanol), separation and analysis of C2-C5 hydrocarbons, and can separate positive , isobutene and cis and trans-butene. Pesticide residue analysis. Organic Synthesis. Peptide synthesis. For the photographic industry.